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Essential Measures are only those items that are critical to the collection of the Measure or are necessary for the interpretation of results. Essential Measures are integral to the Measure. Without such information the data collected would be incomplete and/or misleading.
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Browse » Domains » Diabetes » Fasting C-peptide Assay

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Measure: Fasting C-peptide Assay   #141200


A bioassay to measure serum concentration of C-peptide (connecting peptide), a small peptide that is cleaved from the proinsulin protein to form an active insulin protein. This peptide is produced by the pancreas as a by-product of insulin processing. It is secreted together with insulin.


C-peptide levels may be used to differentiate type 1 from type 2 diabetes. People whose pancreas does not make any insulin (type 1 diabetes) have low levels of insulin and C-peptide. A person with type 2 diabetes has a normal or high level of C-peptide. C-peptide levels can be a more sensitive test of pancreas activity than insulin because they are not confounded by insulin replacement therapy. (Marques et al., 2004; ADA, 2010).



Diabetes, proinsulin, C-peptide, pancreas, hyperglycemia, homeostatic model assessment, HOMA, insulin resistance, NHANES

Measure Release Date: October 1, 2015

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