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Sickle Cell Disease: Cardiovascular, Pulmonary, and Renal Specialty Collection

Browse » Collections » Sickle Cell Disease » Sickle Cell Disease: Cardiovascular, Pulmonary, and Renal Specialty Collection » N-terminal Pro-brain Natriuretic Peptide (NT-proBNP)

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Measure: N-terminal Pro-brain Natriuretic Peptide (NT-proBNP)   #810500

Definition: A bioassay to determine an individual’s level of N-terminal pro-brain natriuretic peptide (NT-proBNP).


N-terminal pro-brain natriuretic peptide (NT-proBNP) is released from the right or left ventricle of the heart when it is under increased strain related to volume or pressure overload. Levels of NT-proBNP can be used as a screening tool to evaluate an individual’s left and right ventricular function. Elevated NT-proBNP levels can be used diagnostically in decompensated congestive heart failure and they can be followed longitudinally to understand response to therapy. In patients with pulmonary hypertension and acute pulmonary embolism, elevated levels reflect an increased risk of morbidity and mortality. Additionally, in patients with sickle cell disease, levels of NT-proBNP levels > 160 pg/ml predict increased mortality risk.


Keywords: N-terminal pro-brain natriuretic peptide, NT-proBNP, left ventricular ejection fraction, LVEF, sickle cell disease, SCD, chronic heart failure, pulmonary hypertension, PH, biomarkers, immunoassay

Measure Release Date: July 30, 2015

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